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;In vivo: MK-4827 is nicely tolerated in vivo and demonstrates efficacy as one agent in a xenograft design of BRCA-1 deficient cancer [1]. In addition, MK-4827 strongly improves the result of radiation on a variety of human tumor xenografts, equally p53 wild type and p53 mutant. The enhancement of radiation response is observed in clinically applic

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